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The authors of the American College of Chest Physicians Updates on Cough Guidelines (2006) recommend that, for cough associated with the common cold, first-generation antihistamine-decongestants are more effective than newer, non-sedating antihistamines.
These symptoms may be due to hay fever, other upper respiratory allergies, or the common cold.
The reason for their peripheral selectivity is that most of these compounds are zwitterionic at physiological p H (around p H 7.4).
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