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Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension and death in patients with sickle cell disease.
Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM Jr, Gladwin MT. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
He takes care of adults with sickle cell disease, and leads clinical and laboratory bench research to learn the causes of pulmonary hypertension and other forms of vascular dysfunction and to develop new treatments to improve or prevent it. Nguyen KL, Tian X, Alam S, Mehari A, Leung SW, Seamon C, Allen D, Minniti CP, Sachdev V, Arai AE, Kato GJ. Minniti CP, Gorbach AM, Xu D, Hon YY, Delaney KM, Seidel M, Malik N, Peters-Lawrence M, Cantilena C, Nichols JS, Mendelsohn L, Conrey A, Grimes G, Kato GJ. Topical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: a phase 1 dose-finding safety and tolerability trial.
He has a highly collaborative team of clinical and laboratory researchers and a group of motivated, committed patients that enables us to make progress in this research. Kato's research specialties have been in blood flow physiology studies, clinical trials and proteomic analysis of plasma to unravel new mechanisms contributing to complications of sickle cell disease and to the development of red blood cells in the bone marrow. New insights into sickle cell disease: mechanisms and investigational therapies. Elevated transpulmonary gradient and cardiac magnetic resonance-derived right ventricular remodeling predict poor outcomes in sickle cell disease.
Greg Siegle , Associate Professor of Psychiatry, Psychology and Clinical and Translational Studies , who was awarded the 2019 Frijda Chair in Cognitive Science at the University of Amsterdam. Siegle’s research focuses on examining the neurophysiological substrates of cognition and emotion in depression and anxiety using self-report, behavioral, physiological and neuroimaging (f MRI)...
The 19th annual Department of Psychiatry Research Day on June 13, 2019 was our biggest yet!
Professor of Medicine, Division of Hematology/Oncology Director, Sickle Cell Center of Excellence E1240 BST 200 Lothrop Street Pittsburgh, PA 15261 Phone: 412-648-3017 Lab Phone: 412-624-7426 Email: [email protected] Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis.
Kato is a hematologist with an active translational research interest in sickle cell disease, especially disorders of the blood vessel wall that may contribute to pulmonary hypertension.
Mortality in adults with sickle cell disease and pulmonary hypertension.
His 10-year stint in the Bucs front office included work in the Sales, Public Relations and Broadcasting departments.
Greg also served as the team's public address announcer during the 1987 campaign.
He and his team have formulated a model to suggest that pulmonary hypertension, stroke, leg ulcers and priapism share features of vasculopathy and more severe hemolytic anemia, and that pain crisis, acute chest syndrome and avascular necrosis share evidence of poor blood circulation due to viscosity. Hosseini P, Abidi SZ, Du E, Papageorgiou DP, Choi Y, Park Y, Higgins JM, Kato GJ, Suresh S, Dao M, Yaqoob Z, So PT.
These two groups overlap and are not completely distinct. Kato joined the Vascular Medicine Institute in September 2013. New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo? Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease.
Villagra J, Shiva S, Hunter LA, Machado RF, Gladwin MT, Kato GJ. Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension and nitric oxide scavenging by cell-free hemoglobin.